Can MI300X 192GB run Mixtral-8x7B-Instruct-v0.1?

AMD · 192 GB HBM3 · 5300 GB/s bandwidth · Mistral · 46.7B (active 12.9B) · MoE · model ctx up to 32K

Yes — the MI300X 192GB (192 GB HBM3) can run Mixtral-8x7B-Instruct-v0.1. At Q4 with the default 8K context it needs ≈ 29.27 GB VRAM (weights 25.69 GB + KV cache 2.58 GB + 1 GB runtime overhead), which fits within 192 GB. Decode at Q4/8K: ≈ 261.5 tok/s (estimated, batch 1). FP16 (≈ 96.98 GB) also fits, at ≈ 71.9 tok/s (estimated). Estimates come from memory-bandwidth math; rows tagged measured override estimates. Relative ranking is more reliable than absolute tok/s. Methodology.

Fit & speed by quant and context

Quant	Context	VRAM needed	Fits?	tok/s (decode)
Q4	4K	27.98 GB	Yes	261.5 est.
Q4	8K default	29.27 GB	Yes	261.5 est.
Q4	32K	37.01 GB	Yes	261.5 est.
FP16	4K	95.69 GB	Yes	71.9 est.
FP16	8K default	96.98 GB	Yes	71.9 est.
FP16	32K	104.72 GB	Yes	71.9 est.

Fits = weights + KV(ctx) + 1 GB overhead ≤ 95% of VRAM. Measured anchors are context-agnostic; the fit verdict is recomputed per context. A missing tok/s means the model is far beyond this card (offload-only territory).

VRAM breakdown at 8K context

Quant	Weights	KV cache	Overhead	Total needed	MI300X 192GB VRAM
Q4	25.69 GB	2.58 GB	1 GB	29.27 GB	192 GB
FP16	93.4 GB	2.58 GB	1 GB	96.98 GB	192 GB

Other GPUs that run Mixtral-8x7B-Instruct-v0.1

• B200 192GB SXM — ≈394.6 tok/s Q4 est.
• H200 141GB SXM5 — ≈236.8 tok/s Q4 est.
• H100 80GB SXM5 — ≈165.3 tok/s Q4 est.
• Gaudi 3 128GB — ≈161.6 tok/s Q4 est.
• A100 80GB SXM4 — ≈100.6 tok/s Q4 est.
• RTX 5090 32GB — ≈88.4 tok/s Q4 est.
• RTX 6000 Ada 48GB — ≈47.4 tok/s Q4 est.
• L40S 48GB — ≈42.6 tok/s Q4 est.

All GPUs for Mixtral-8x7B-Instruct-v0.1 →

Other models for the MI300X 192GB

• Qwen3-0.6B — ≈4215.9 tok/s Q4 est.
• gemma-3-1b-it — ≈3372.7 tok/s Q4 est.
• Llama-3.2-1B-Instruct — ≈2810.6 tok/s Q4 est.
• Qwen3-1.7B — ≈1686.4 tok/s Q4 est.
• Qwen3-30B-A3B — ≈1124.2 tok/s Q4 est.
• Qwen3-Coder-30B-A3B-Instruct — ≈1124.2 tok/s Q4 est.
• GLM-4.7-Flash — ≈1124.2 tok/s Q4 est.
• Qwen3-30B-A3B-Instruct-2507 — ≈1124.2 tok/s Q4 est.

All models on the MI300X 192GB →