Can H100 80GB SXM5 run Mixtral-8x7B-Instruct-v0.1?

NVIDIA · 80 GB HBM3 · 3350 GB/s bandwidth · Mistral · 46.7B (active 12.9B) · MoE · model ctx up to 32K

Yes — the H100 80GB SXM5 (80 GB HBM3) can run Mixtral-8x7B-Instruct-v0.1. At Q4 with the default 8K context it needs ≈ 29.27 GB VRAM (weights 25.69 GB + KV cache 2.58 GB + 1 GB runtime overhead), which fits within 80 GB. Decode at Q4/8K: ≈ 165.3 tok/s (estimated, batch 1). FP16 needs ≈ 96.98 GB — does not fit on this card. Estimates come from memory-bandwidth math; rows tagged measured override estimates. Relative ranking is more reliable than absolute tok/s. Methodology.

Fit & speed by quant and context

Quant	Context	VRAM needed	Fits?	tok/s (decode)
Q4	4K	27.98 GB	Yes	165.3 est.
Q4	8K default	29.27 GB	Yes	165.3 est.
Q4	32K	37.01 GB	Yes	165.3 est.
FP16	4K	95.69 GB	No	90.8 est.
FP16	8K default	96.98 GB	No	88.4 est.
FP16	32K	104.72 GB	No	75.8 est.

Fits = weights + KV(ctx) + 1 GB overhead ≤ 95% of VRAM. Measured anchors are context-agnostic; the fit verdict is recomputed per context. A missing tok/s means the model is far beyond this card (offload-only territory).

VRAM breakdown at 8K context

Quant	Weights	KV cache	Overhead	Total needed	H100 80GB SXM5 VRAM
Q4	25.69 GB	2.58 GB	1 GB	29.27 GB	80 GB
FP16	93.4 GB	2.58 GB	1 GB	96.98 GB	80 GB

Other GPUs that run Mixtral-8x7B-Instruct-v0.1

• B200 192GB SXM — ≈394.6 tok/s Q4 est.
• MI300X 192GB — ≈261.5 tok/s Q4 est.
• H200 141GB SXM5 — ≈236.8 tok/s Q4 est.
• Gaudi 3 128GB — ≈161.6 tok/s Q4 est.
• A100 80GB SXM4 — ≈100.6 tok/s Q4 est.
• RTX 5090 32GB — ≈88.4 tok/s Q4 est.
• RTX 6000 Ada 48GB — ≈47.4 tok/s Q4 est.
• L40S 48GB — ≈42.6 tok/s Q4 est.

All GPUs for Mixtral-8x7B-Instruct-v0.1 →

Other models for the H100 80GB SXM5

• Qwen3-0.6B — ≈2664.8 tok/s Q4 est.
• gemma-3-1b-it — ≈2131.8 tok/s Q4 est.
• Llama-3.2-1B-Instruct — ≈1776.5 tok/s Q4 est.
• Qwen3-1.7B — ≈1065.9 tok/s Q4 est.
• Qwen3-30B-A3B — ≈710.6 tok/s Q4 est.
• Qwen3-Coder-30B-A3B-Instruct — ≈710.6 tok/s Q4 est.
• GLM-4.7-Flash — ≈710.6 tok/s Q4 est.
• Qwen3-30B-A3B-Instruct-2507 — ≈710.6 tok/s Q4 est.

All models on the H100 80GB SXM5 →