Can MI300X 192GB run Mistral-Medium-3.5-128B?

AMD · 192 GB HBM3 · 5300 GB/s bandwidth · Mistral · 128.0B · model ctx up to 256K

Yes — the MI300X 192GB (192 GB HBM3) can run Mistral-Medium-3.5-128B. At Q4 with the default 8K context it needs ≈ 97.0 GB VRAM (weights 70.4 GB + KV cache 25.6 GB + 1 GB runtime overhead), which fits within 192 GB. Decode at Q4/8K: ≈ 26.3 tok/s (estimated, batch 1). FP16 needs ≈ 282.6 GB — does not fit on this card. Estimates come from memory-bandwidth math; rows tagged measured override estimates. Relative ranking is more reliable than absolute tok/s. Methodology.

Fit & speed by quant and context

Quant	Context	VRAM needed	Fits?	tok/s (decode)
Q4	4K	84.2 GB	Yes	26.3 est.
Q4	8K default	97.0 GB	Yes	26.3 est.
Q4	32K	173.8 GB	Yes	26.3 est.
FP16	4K	269.8 GB	No	10.5 est.
FP16	8K default	282.6 GB	No	9.6 est.
FP16	32K	359.4 GB	No	5.9 est.

Fits = weights + KV(ctx) + 1 GB overhead ≤ 95% of VRAM. Measured anchors are context-agnostic; the fit verdict is recomputed per context. A missing tok/s means the model is far beyond this card (offload-only territory).

VRAM breakdown at 8K context

Quant	Weights	KV cache	Overhead	Total needed	MI300X 192GB VRAM
Q4	70.4 GB	25.6 GB	1 GB	97.0 GB	192 GB
FP16	256.0 GB	25.6 GB	1 GB	282.6 GB	192 GB

Other GPUs that run Mistral-Medium-3.5-128B

• B200 192GB SXM — ≈39.8 tok/s Q4 est.
• H200 141GB SXM5 — ≈23.9 tok/s Q4 est.
• Gaudi 3 128GB — ≈16.3 tok/s Q4 est.
• Mac Studio M2 Ultra 192GB — ≈4.0 tok/s Q4 est.
• MacBook Pro M4 Max 128GB — ≈2.7 tok/s Q4 est.
• MacBook Pro M3 Max 128GB — ≈2.0 tok/s Q4 est.

All GPUs for Mistral-Medium-3.5-128B →

Other models for the MI300X 192GB

• MiniCPM5-1B — ≈3122.9 tok/s Q4 est.
• Qwen3.5-2B — ≈1686.4 tok/s Q4 est.
• GLM-4.7-Flash — ≈1124.2 tok/s Q4 est.
• Qwen3-30B-A3B-Instruct-2507 — ≈1124.2 tok/s Q4 est.
• Qwen3-Next-80B-A3B-Instruct — ≈1124.2 tok/s Q4 est.
• Qwen3-Coder-Next — ≈1124.2 tok/s Q4 est.
• Qwen3.5-35B-A3B — ≈1124.2 tok/s Q4 est.
• Qwen3.6-35B-A3B — ≈1124.2 tok/s Q4 est.

All models on the MI300X 192GB →