Can Ryzen AI Max+ 395 64GB run Qwen3.5-122B-A10B?

AMD · 48 GB LPDDR5X · 215 GB/s bandwidth · Alibaba · 122.0B (active 10.0B) · MoE · model ctx up to 256K

ROCM

No — Qwen3.5-122B-A10B at Q4 needs ≈ 68.23 GB even at 4K context, beyond the Ryzen AI Max+ 395 64GB's 48 GB LPDDR5X. It would only run with heavy CPU/disk offload. Decode at Q4/8K: ≈ 19.3 tok/s (estimated, batch 1). FP16 needs ≈ 245.25 GB — does not fit on this card. Estimates come from memory-bandwidth math; rows tagged measured override estimates. Relative ranking is more reliable than absolute tok/s. Methodology.

Fit & speed by quant and context

Quant	Context	VRAM needed	Fits?	tok/s (decode)
Q4	4K	68.23 GB	No	19.3 est.
Q4	8K default	68.35 GB	No	19.3 est.
Q4	32K	69.1 GB	No	18.8 est.
FP16	4K	245.12 GB	No	—
FP16	8K default	245.25 GB	No	—
FP16	32K	246.0 GB	No	—

Fits = weights + KV(ctx) + 1 GB overhead ≤ 95% of VRAM. Measured anchors are context-agnostic; the fit verdict is recomputed per context. A missing tok/s means the model is far beyond this card (offload-only territory).

VRAM breakdown at 8K context

Quant	Weights	KV cache	Overhead	Total needed	Ryzen AI Max+ 395 64GB VRAM
Q4	67.1 GB	0.25 GB	1 GB	68.35 GB	48 GB
FP16	244.0 GB	0.25 GB	1 GB	245.25 GB	48 GB

Other GPUs that run Qwen3.5-122B-A10B

• B200 192GB SXM — ≈509.1 tok/s Q4 est.
• MI300X 192GB — ≈337.3 tok/s Q4 est.
• H200 141GB SXM5 — ≈305.5 tok/s Q4 est.
• H100 80GB SXM5 — ≈213.2 tok/s Q4 est.
• Gaudi 3 128GB — ≈208.5 tok/s Q4 est.
• A100 80GB SXM4 — ≈129.8 tok/s Q4 est.
• Mac Studio M3 Ultra 96GB — ≈52.1 tok/s Q4 est.
• Mac Studio M2 Ultra 192GB — ≈50.9 tok/s Q4 est.

All GPUs for Qwen3.5-122B-A10B →

Other models for the Ryzen AI Max+ 395 64GB

• MiniCPM5-1B — ≈126.7 tok/s Q4 est.
• Qwen3.5-2B — ≈68.4 tok/s Q4 est.
• DeepSeek-R1-0528-Qwen3-8B-layer-mix-bpw-3.8-mlx — ≈59.5 tok/s Q4 est.
• Qwen3.6-35B-A3B — ≈45.6 tok/s Q4 est.
• Qwen3.5-35B-A3B — ≈45.6 tok/s Q4 est.
• GLM-4.7-Flash — ≈45.6 tok/s Q4 est.
• Qwen3-30B-A3B-Instruct-2507 — ≈45.6 tok/s Q4 est.
• Nemotron-3-Nano-Omni-30B-A3B-Reasoning-BF16 — ≈45.6 tok/s Q4 est.

All models on the Ryzen AI Max+ 395 64GB →