Yes — the Ryzen AI Max+ 395 64GB (48 GB LPDDR5X) can run Qwen3.5-2B. At Q4 with the default 8K context it needs ≈ 2.15 GB VRAM (weights 1.1 GB + KV cache 0.05 GB + 1 GB runtime overhead), which fits within 48 GB. Decode at Q4/8K: ≈ 68.4 tok/s (estimated, batch 1). FP16 (≈ 5.05 GB) also fits, at ≈ 18.8 tok/s (estimated). Estimates come from memory-bandwidth math; rows tagged measured override estimates. Relative ranking is more reliable than absolute tok/s. Methodology.
Fit & speed by quant and context
Quant
Context
VRAM needed
Fits?
tok/s (decode)
Q4
4K
2.12 GB
Yes
68.4est.
Q4
8K default
2.15 GB
Yes
68.4est.
Q4
32K
2.3 GB
Yes
68.4est.
FP16
4K
5.03 GB
Yes
18.8est.
FP16
8K default
5.05 GB
Yes
18.8est.
FP16
32K
5.2 GB
Yes
18.8est.
Fits = weights + KV(ctx) + 1 GB overhead ≤ 95% of VRAM. Measured anchors are context-agnostic; the fit verdict is recomputed per context. A missing tok/s means the model is far beyond this card (offload-only territory).