Can Ryzen AI Max+ 395 64GB run Qwen2.5-72B-Instruct?

AMD · 48 GB LPDDR5X · 215 GB/s bandwidth · Alibaba · 72.7B · model ctx up to 128K

ROCM

No — Qwen2.5-72B-Instruct at Q4 needs ≈ 48.26 GB even at 4K context, beyond the Ryzen AI Max+ 395 64GB's 48 GB LPDDR5X. It would only run with heavy CPU/disk offload. Decode at Q4/8K: ≈ 4.0 tok/s (estimated, batch 1). FP16 needs ≈ 160.94 GB — does not fit on this card. Estimates come from memory-bandwidth math; rows tagged measured override estimates. Relative ranking is more reliable than absolute tok/s. Methodology.

Fit & speed by quant and context

Quant	Context	VRAM needed	Fits?	tok/s (decode)
Q4	4K	48.26 GB	No	5.3 est.
Q4	8K default	55.53 GB	No	4.0 est.
Q4	32K	99.15 GB	No	1.3 est.
FP16	4K	153.67 GB	No	0.1 est.
FP16	8K default	160.94 GB	No	0.1 est.
FP16	32K	204.56 GB	No	—

Fits = weights + KV(ctx) + 1 GB overhead ≤ 95% of VRAM. Measured anchors are context-agnostic; the fit verdict is recomputed per context. A missing tok/s means the model is far beyond this card (offload-only territory).

VRAM breakdown at 8K context

Quant	Weights	KV cache	Overhead	Total needed	Ryzen AI Max+ 395 64GB VRAM
Q4	39.99 GB	14.54 GB	1 GB	55.53 GB	48 GB
FP16	145.4 GB	14.54 GB	1 GB	160.94 GB	48 GB

Other GPUs that run Qwen2.5-72B-Instruct

• B200 192GB SXM — ≈70.0 tok/s Q4 est.
• MI300X 192GB — ≈46.4 tok/s Q4 est.
• H200 141GB SXM5 — ≈42.0 tok/s Q4 est.
• H100 80GB SXM5 — ≈29.3 tok/s Q4 est.
• Gaudi 3 128GB — ≈28.7 tok/s Q4 est.
• A100 80GB SXM4 — ≈16.47 tok/s Q4 measured
• MacBook Pro M4 Max 128GB — ≈11.0 tok/s Q4 measured
• Mac Studio M3 Ultra 96GB — ≈7.2 tok/s Q4 est.

All GPUs for Qwen2.5-72B-Instruct →

Other models for the Ryzen AI Max+ 395 64GB

• MiniCPM5-1B — ≈126.7 tok/s Q4 est.
• Qwen3.5-2B — ≈68.4 tok/s Q4 est.
• DeepSeek-R1-0528-Qwen3-8B-layer-mix-bpw-3.8-mlx — ≈59.5 tok/s Q4 est.
• Qwen3.6-35B-A3B — ≈45.6 tok/s Q4 est.
• Qwen3.5-35B-A3B — ≈45.6 tok/s Q4 est.
• GLM-4.7-Flash — ≈45.6 tok/s Q4 est.
• Qwen3-30B-A3B-Instruct-2507 — ≈45.6 tok/s Q4 est.
• Nemotron-3-Nano-Omni-30B-A3B-Reasoning-BF16 — ≈45.6 tok/s Q4 est.

All models on the Ryzen AI Max+ 395 64GB →