Mac mini M4 Pro 64GB vs MI300X 192GB for Local LLMs
The MI300X 192GB has about 1841% more memory bandwidth (5,300 vs 273 GB/s). Batch-1 decode tracks bandwidth closely, so a model that fits both cards should decode roughly 1841% faster on the MI300X 192GB. The MI300X 192GB fits more of the catalog at Q4/8K — 50 vs 44 of 61 models (192 vs 64 GB VRAM). Largest model that fits the MI300X 192GB but not the Mac mini M4 Pro 64GB: Qwen3-235B-A22B (235.1B). MSRP is $2,199 for the Mac mini M4 Pro 64GB vs $15,000 for the MI300X 192GB. MSRP is a launch list price, not live retail — Amazon prices move; click through for the current price. Not retail-shoppable: MI300X 192GB (datacenter-class; cloud rental is the realistic way to use it). In the Q4/8K head-to-head below (51 shared models), the MI300X 192GB posts the higher tok/s in 51 rows vs 0. Methodology.