Can RTX 5080 16GB run gemma-4-26B-A4B-it?

NVIDIA · 16 GB GDDR7 · 960 GB/s bandwidth · Google · 25.2B (active 3.8B) · MoE · model ctx up to 256K

No — gemma-4-26B-A4B-it at Q4 needs ≈ 15.24 GB even at 4K context, beyond the RTX 5080 16GB's 16 GB GDDR7. It would only run with heavy CPU/disk offload. Decode at Q4/8K: ≈ 482.0 tok/s (estimated, batch 1). FP16 needs ≈ 52.16 GB — does not fit on this card. Estimates come from memory-bandwidth math; rows tagged measured override estimates. Relative ranking is more reliable than absolute tok/s. Methodology.

Fit & speed by quant and context

Quant	Context	VRAM needed	Fits?	tok/s (decode)
Q4	4K	15.24 GB	No	506.3 est.
Q4	8K default	15.62 GB	No	482.0 est.
Q4	32K	17.9 GB	No	367.0 est.
FP16	4K	51.78 GB	No	12.1 est.
FP16	8K default	52.16 GB	No	11.9 est.
FP16	32K	54.44 GB	No	10.9 est.

Fits = weights + KV(ctx) + 1 GB overhead ≤ 95% of VRAM. Measured anchors are context-agnostic; the fit verdict is recomputed per context. A missing tok/s means the model is far beyond this card (offload-only territory).

VRAM breakdown at 8K context

Quant	Weights	KV cache	Overhead	Total needed	RTX 5080 16GB VRAM
Q4	13.86 GB	0.76 GB	1 GB	15.62 GB	16 GB
FP16	50.4 GB	0.76 GB	1 GB	52.16 GB	16 GB

Other GPUs that run gemma-4-26B-A4B-it

• B200 192GB SXM — ≈1339.7 tok/s Q4 est.
• MI300X 192GB — ≈887.6 tok/s Q4 est.
• H200 141GB SXM5 — ≈803.8 tok/s Q4 est.
• H100 80GB SXM5 — ≈561.0 tok/s Q4 est.
• Gaudi 3 128GB — ≈548.6 tok/s Q4 est.
• A100 80GB SXM4 — ≈341.5 tok/s Q4 est.
• RTX 5090 32GB — ≈300.1 tok/s Q4 est.
• RTX 4090 24GB — ≈168.8 tok/s Q4 est.

All GPUs for gemma-4-26B-A4B-it →

Other models for the RTX 5080 16GB

• MiniCPM5-1B — ≈565.7 tok/s Q4 est.
• Qwen3.5-2B — ≈305.5 tok/s Q4 est.
• gpt-oss-20b — ≈204.9 tok/s Q4 measured
• Llama-3.2-3B-Instruct — ≈190.9 tok/s Q4 est.
• Mistral-7B-Instruct-v0.3 — ≈163.6 tok/s Q4 measured
• Qwen3-4B-Instruct-2507 — ≈152.7 tok/s Q4 est.
• Qwen3-4B-Thinking-2507 — ≈152.7 tok/s Q4 est.
• NVIDIA-Nemotron-3-Nano-4B-BF16 — ≈152.7 tok/s Q4 est.

All models on the RTX 5080 16GB →