Can Mac mini M4 Pro 64GB run Qwen3.5-122B-A10B?

Apple · 64 GB LPDDR5X · 273 GB/s bandwidth · Alibaba · 122.0B (active 10.0B) · MoE · model ctx up to 256K

No — Qwen3.5-122B-A10B at Q4 needs ≈ 69.1 GB even at 4K context, beyond the Mac mini M4 Pro 64GB's 64 GB LPDDR5X. It would only run with heavy CPU/disk offload. Decode at Q4/8K: ≈ 41.4 tok/s (estimated, batch 1). FP16 needs ≈ 247.0 GB — does not fit on this card. Estimates come from memory-bandwidth math; rows tagged measured override estimates. Relative ranking is more reliable than absolute tok/s. Methodology.

Fit & speed by quant and context

Quant	Context	VRAM needed	Fits?	tok/s (decode)
Q4	4K	69.1 GB	No	42.6 est.
Q4	8K default	70.1 GB	No	41.4 est.
Q4	32K	76.1 GB	No	35.1 est.
FP16	4K	246.0 GB	No	0.9 est.
FP16	8K default	247.0 GB	No	0.9 est.
FP16	32K	253.0 GB	No	0.9 est.

Fits = weights + KV(ctx) + 1 GB overhead ≤ 95% of VRAM. Measured anchors are context-agnostic; the fit verdict is recomputed per context. A missing tok/s means the model is far beyond this card (offload-only territory).

VRAM breakdown at 8K context

Quant	Weights	KV cache	Overhead	Total needed	Mac mini M4 Pro 64GB VRAM
Q4	67.1 GB	2.0 GB	1 GB	70.1 GB	64 GB
FP16	244.0 GB	2.0 GB	1 GB	247.0 GB	64 GB

Other GPUs that run Qwen3.5-122B-A10B

• B200 192GB SXM — ≈509.1 tok/s Q4 est.
• MI300X 192GB — ≈337.3 tok/s Q4 est.
• H200 141GB SXM5 — ≈305.5 tok/s Q4 est.
• H100 80GB SXM5 — ≈213.2 tok/s Q4 est.
• Gaudi 3 128GB — ≈208.5 tok/s Q4 est.
• A100 80GB SXM4 — ≈129.8 tok/s Q4 est.
• Mac Studio M3 Ultra 96GB — ≈52.1 tok/s Q4 est.
• Mac Studio M2 Ultra 192GB — ≈50.9 tok/s Q4 est.

All GPUs for Qwen3.5-122B-A10B →

Other models for the Mac mini M4 Pro 64GB

• MiniCPM5-1B — ≈160.9 tok/s Q4 est.
• Qwen3.5-2B — ≈86.9 tok/s Q4 est.
• GLM-4.7-Flash — ≈57.9 tok/s Q4 est.
• Qwen3-30B-A3B-Instruct-2507 — ≈57.9 tok/s Q4 est.
• Qwen3-Next-80B-A3B-Instruct — ≈57.9 tok/s Q4 est.
• Qwen3-Coder-Next — ≈57.9 tok/s Q4 est.
• Qwen3.5-35B-A3B — ≈57.9 tok/s Q4 est.
• Qwen3.6-35B-A3B — ≈57.9 tok/s Q4 est.

All models on the Mac mini M4 Pro 64GB →