Can MacBook Pro M1 Max 64GB run Qwen2.5-72B-Instruct?

Apple · 64 GB LPDDR5 · 400 GB/s bandwidth · Alibaba · 72.7B · model ctx up to 128K

METAL

Yes — the MacBook Pro M1 Max 64GB (64 GB LPDDR5) can run Qwen2.5-72B-Instruct. At Q4 with the default 8K context it needs ≈ 55.53 GB VRAM (weights 39.99 GB + KV cache 14.54 GB + 1 GB runtime overhead), which fits within 64 GB. Decode at Q4/8K: ≈ 3.5 tok/s (estimated, batch 1). FP16 needs ≈ 160.94 GB — does not fit on this card. Estimates come from memory-bandwidth math; rows tagged measured override estimates. Relative ranking is more reliable than absolute tok/s. Methodology. Buy MacBook Pro M1 Max 64GB on Amazon →

Fit & speed by quant and context

Quant	Context	VRAM needed	Fits?	tok/s (decode)
Q4	4K	48.26 GB	Yes	3.5 ± est.
Q4	8K default	55.53 GB	Yes	3.5 ± est.
Q4	32K	99.15 GB	No	4.2 ± est.
FP16	4K	153.67 GB	No	0.5 ± est.
FP16	8K default	160.94 GB	No	0.4 ± est.
FP16	32K	204.56 GB	No	0.3 ± est.

Fits = weights + KV(ctx) + 1 GB overhead ≤ 95% of VRAM. Measured anchors are context-agnostic; the fit verdict is recomputed per context. A missing tok/s means the model is far beyond this card (offload-only territory).

VRAM breakdown at 8K context

Quant	Weights	KV cache	Overhead	Total needed	MacBook Pro M1 Max 64GB VRAM
Q4	39.99 GB	14.54 GB	1 GB	55.53 GB	64 GB
FP16	145.4 GB	14.54 GB	1 GB	160.94 GB	64 GB

Other GPUs that run Qwen2.5-72B-Instruct

• B200 192GB SXM — ≈70.0 tok/s Q4 est.
• MI300X 192GB — ≈46.4 tok/s Q4 est.
• H200 141GB SXM5 — ≈42.0 tok/s Q4 est.
• H100 80GB SXM5 — ≈29.3 tok/s Q4 est.
• Gaudi 3 128GB — ≈28.7 tok/s Q4 est.
• A100 80GB SXM4 — ≈16.47 tok/s Q4 measured
• MacBook Pro M4 Max 128GB — ≈11.0 tok/s Q4 measured
• Mac Studio M3 Ultra 96GB — ≈7.2 tok/s Q4 est.

All GPUs for Qwen2.5-72B-Instruct →

Other models for the MacBook Pro M1 Max 64GB

• MiniCPM5-1B — ≈235.7 tok/s Q4 est.
• Qwen3.5-2B — ≈127.3 tok/s Q4 est.
• DeepSeek-R1-0528-Qwen3-8B-layer-mix-bpw-3.8-mlx — ≈110.7 tok/s Q4 est.
• Qwen3.6-35B-A3B — ≈84.8 tok/s Q4 est.
• Qwen3.5-35B-A3B — ≈84.8 tok/s Q4 est.
• GLM-4.7-Flash — ≈84.8 tok/s Q4 est.
• Qwen3-30B-A3B-Instruct-2507 — ≈84.8 tok/s Q4 est.
• Nemotron-3-Nano-Omni-30B-A3B-Reasoning-BF16 — ≈84.8 tok/s Q4 est.

All models on the MacBook Pro M1 Max 64GB →