Can Ryzen AI Max+ 395 128GB run Qwen3-235B-A22B-Instruct-2507?

AMD · 96 GB LPDDR5X · 215 GB/s bandwidth · Alibaba · 235.1B (active 22B) · MoE · model ctx up to 256K

ROCM

No — Qwen3-235B-A22B-Instruct-2507 at Q4 needs ≈ 132.5 GB even at 4K context, beyond the Ryzen AI Max+ 395 128GB's 96 GB LPDDR5X. It would only run with heavy CPU/disk offload. Decode at Q4/8K: ≈ 9.0 tok/s (estimated, batch 1). FP16 needs ≈ 475.6 GB — does not fit on this card. Estimates come from memory-bandwidth math; rows tagged measured override estimates. Relative ranking is more reliable than absolute tok/s. Methodology.

Fit & speed by quant and context

Quant	Context	VRAM needed	Fits?	tok/s (decode)
Q4	4K	132.5 GB	No	9.3 est.
Q4	8K default	134.71 GB	No	9.0 est.
Q4	32K	147.91 GB	No	7.5 est.
FP16	4K	473.4 GB	No	—
FP16	8K default	475.6 GB	No	—
FP16	32K	488.8 GB	No	—

Fits = weights + KV(ctx) + 1 GB overhead ≤ 95% of VRAM. Measured anchors are context-agnostic; the fit verdict is recomputed per context. A missing tok/s means the model is far beyond this card (offload-only territory).

VRAM breakdown at 8K context

Quant	Weights	KV cache	Overhead	Total needed	Ryzen AI Max+ 395 128GB VRAM
Q4	129.31 GB	4.4 GB	1 GB	134.71 GB	96 GB
FP16	470.2 GB	4.4 GB	1 GB	475.6 GB	96 GB

Other GPUs that run Qwen3-235B-A22B-Instruct-2507

• B200 192GB SXM — ≈231.4 tok/s Q4 est.
• MI300X 192GB — ≈153.3 tok/s Q4 est.
• H200 141GB SXM5 — ≈138.8 tok/s Q4 est.
• Mac Studio M2 Ultra 192GB — ≈23.1 tok/s Q4 est.
• DGX Spark (GH200 480GB) — ≈14.5 tok/s Q4 est.

All GPUs for Qwen3-235B-A22B-Instruct-2507 →

Other models for the Ryzen AI Max+ 395 128GB

• MiniCPM5-1B — ≈126.7 tok/s Q4 est.
• Qwen3.5-2B — ≈68.4 tok/s Q4 est.
• DeepSeek-R1-0528-Qwen3-8B-layer-mix-bpw-3.8-mlx — ≈59.5 tok/s Q4 est.
• Qwen3.6-35B-A3B — ≈45.6 tok/s Q4 est.
• Qwen3.5-35B-A3B — ≈45.6 tok/s Q4 est.
• GLM-4.7-Flash — ≈45.6 tok/s Q4 est.
• Qwen3-30B-A3B-Instruct-2507 — ≈45.6 tok/s Q4 est.
• Nemotron-3-Nano-Omni-30B-A3B-Reasoning-BF16 — ≈45.6 tok/s Q4 est.

All models on the Ryzen AI Max+ 395 128GB →