Can Ryzen AI Max 390 64GB run Qwen3.5-397B-A17B?

AMD · 48 GB LPDDR5X · 215 GB/s bandwidth · Alibaba · 397.0B (active 17.0B) · MoE · model ctx up to 256K

ROCM

No — Qwen3.5-397B-A17B at Q4 needs ≈ 219.56 GB even at 4K context, beyond the Ryzen AI Max 390 64GB's 48 GB LPDDR5X. It would only run with heavy CPU/disk offload. FP16 needs ≈ 795.42 GB — does not fit on this card. Estimates come from memory-bandwidth math; rows tagged measured override estimates. Relative ranking is more reliable than absolute tok/s. Methodology.

Fit & speed by quant and context

Quant	Context	VRAM needed	Fits?	tok/s (decode)
Q4	4K	219.56 GB	No	—
Q4	8K default	219.78 GB	No	—
Q4	32K	221.05 GB	No	—
FP16	4K	795.21 GB	No	—
FP16	8K default	795.42 GB	No	—
FP16	32K	796.7 GB	No	—

Fits = weights + KV(ctx) + 1 GB overhead ≤ 95% of VRAM. Measured anchors are context-agnostic; the fit verdict is recomputed per context. A missing tok/s means the model is far beyond this card (offload-only territory).

VRAM breakdown at 8K context

Quant	Weights	KV cache	Overhead	Total needed	Ryzen AI Max 390 64GB VRAM
Q4	218.35 GB	0.43 GB	1 GB	219.78 GB	48 GB
FP16	794.0 GB	0.43 GB	1 GB	795.42 GB	48 GB

Other GPUs that run Qwen3.5-397B-A17B

• DGX Spark (GH200 480GB) — ≈18.7 tok/s Q4 est.

All GPUs for Qwen3.5-397B-A17B →

Other models for the Ryzen AI Max 390 64GB

• MiniCPM5-1B — ≈126.7 tok/s Q4 est.
• Qwen3.5-2B — ≈68.4 tok/s Q4 est.
• DeepSeek-R1-0528-Qwen3-8B-layer-mix-bpw-3.8-mlx — ≈59.5 tok/s Q4 est.
• Qwen3.6-35B-A3B — ≈45.6 tok/s Q4 est.
• Qwen3.5-35B-A3B — ≈45.6 tok/s Q4 est.
• GLM-4.7-Flash — ≈45.6 tok/s Q4 est.
• Qwen3-30B-A3B-Instruct-2507 — ≈45.6 tok/s Q4 est.
• Nemotron-3-Nano-Omni-30B-A3B-Reasoning-BF16 — ≈45.6 tok/s Q4 est.

All models on the Ryzen AI Max 390 64GB →