Can Ryzen AI Max 390 64GB run Qwen2.5-32B-Instruct?

AMD · 48 GB LPDDR5X · 215 GB/s bandwidth · Alibaba · 32.8B · model ctx up to 128K

ROCM

Yes — the Ryzen AI Max 390 64GB (48 GB LPDDR5X) can run Qwen2.5-32B-Instruct. At Q4 with the default 8K context it needs ≈ 25.6 GB VRAM (weights 18.04 GB + KV cache 6.56 GB + 1 GB runtime overhead), which fits within 48 GB. Decode at Q4/8K: ≈ 4.2 tok/s (estimated, batch 1). FP16 needs ≈ 73.16 GB — does not fit on this card. Estimates come from memory-bandwidth math; rows tagged measured override estimates. Relative ranking is more reliable than absolute tok/s. Methodology.

Fit & speed by quant and context

Quant	Context	VRAM needed	Fits?	tok/s (decode)
Q4	4K	22.32 GB	Yes	4.2 est.
Q4	8K default	25.6 GB	Yes	4.2 est.
Q4	32K	45.28 GB	Yes	4.2 est.
FP16	4K	69.88 GB	No	1.5 est.
FP16	8K default	73.16 GB	No	1.4 est.
FP16	32K	92.84 GB	No	0.9 est.

Fits = weights + KV(ctx) + 1 GB overhead ≤ 95% of VRAM. Measured anchors are context-agnostic; the fit verdict is recomputed per context. A missing tok/s means the model is far beyond this card (offload-only territory).

VRAM breakdown at 8K context

Quant	Weights	KV cache	Overhead	Total needed	Ryzen AI Max 390 64GB VRAM
Q4	18.04 GB	6.56 GB	1 GB	25.6 GB	48 GB
FP16	65.6 GB	6.56 GB	1 GB	73.16 GB	48 GB

Other GPUs that run Qwen2.5-32B-Instruct

• B200 192GB SXM — ≈155.2 tok/s Q4 est.
• MI300X 192GB — ≈102.8 tok/s Q4 est.
• H200 141GB SXM5 — ≈93.1 tok/s Q4 est.
• RTX 5090 32GB — ≈75.0 tok/s Q4 measured
• H100 80GB SXM5 — ≈65.0 tok/s Q4 est.
• Gaudi 3 128GB — ≈63.6 tok/s Q4 est.
• A100 80GB SXM4 — ≈55.83 tok/s Q4 measured
• RTX 6000 Ada 48GB — ≈18.6 tok/s Q4 est.

All GPUs for Qwen2.5-32B-Instruct →

Other models for the Ryzen AI Max 390 64GB

• MiniCPM5-1B — ≈126.7 tok/s Q4 est.
• Qwen3.5-2B — ≈68.4 tok/s Q4 est.
• DeepSeek-R1-0528-Qwen3-8B-layer-mix-bpw-3.8-mlx — ≈59.5 tok/s Q4 est.
• Qwen3.6-35B-A3B — ≈45.6 tok/s Q4 est.
• Qwen3.5-35B-A3B — ≈45.6 tok/s Q4 est.
• GLM-4.7-Flash — ≈45.6 tok/s Q4 est.
• Qwen3-30B-A3B-Instruct-2507 — ≈45.6 tok/s Q4 est.
• Nemotron-3-Nano-Omni-30B-A3B-Reasoning-BF16 — ≈45.6 tok/s Q4 est.

All models on the Ryzen AI Max 390 64GB →